Details

Autor(en) / Beteiligte

• Jones, O.D

Titel

Astrocyte-mediated metaplasticity in the hippocampus: Help or hindrance?

Ist Teil von

• Neuroscience, 2015-11, Vol.309, p.113-124

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights • Synaptic plasticity is critical for healthy cognition and is profoundly affected by disease. • Synaptic plasticity mechanisms are regulated by prior neural activity (metaplasticity). • Astrocytes may mediate certain forms of metaplasticity. • Astrocytes display altered form and function in many pathologies common to the hippocampus. • Astrocyte-mediated metaplasticity may be inhibited or unduly engaged in injury or disease and contribute to pathology.