Details

Autor(en) / Beteiligte

• Carroll, Brett J., MD
• Shah, Ravi V., MD
• Murthy, Venkatesh, MD, PhD
• McCullough, Stephen A., MD
• Reza, Nosheen, MD
• Thomas, Sunu S., MD
• Song, Tae H., MD
• Newton-Cheh, Christopher H., MD, MPH
• Camuso, Janice M., RN
• MacGillivray, Thomas, MD
• Sundt, Thoralf M., MD
• Semigran, Marc J., MD
• Lewis, Gregory D., MD
• Baker, Joshua N., MD
• Garcia, José P., MD

Titel

Clinical Features and Outcomes in Adults With Cardiogenic Shock Supported by Extracorporeal Membrane Oxygenation

Ist Teil von

• The American journal of cardiology, 2015-11, Vol.116 (10), p.1624-1630

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Extracorporeal membrane oxygenation (ECMO) is an increasingly used supportive measure for patients with refractory cardiogenic shock (CS). Despite its increasing use, there remain minimal data regarding which patients with refractory CS are most likely to benefit from ECMO. We retrospectively studied all patients (n = 123) who underwent initiation of ECMO for CS from February 2009 to September 2014 at a single center. Baseline patient characteristics, including demographics, co-morbid illness, cause of CS, available laboratory values, and patient outcomes were analyzed. Overall, 69 patients (56%) were weaned from ECMO, with 48 patients (39%) surviving to discharge. Survivors were younger (50 vs 60 years; p ≤0.0001), had a lower rate of previous smoking (27 vs 56%; p = 0.01) and chronic kidney disease (2% vs 13%; p = 0.03), and had lower lactate measured soon after ECMO initiation (3.1 vs 10.2 mmol/l; p = 0.01). Patients with pulmonary embolism (odds ratio 8.0, 95% confidence interval 2.00 to 31.99; p = 0.01) and acute cardiomyopathy (odds ratio 7.5, 95% confidence interval 1.69 to 33.27; p = 0.01) had a higher rate of survival than acute myocardial infarction, chronic cardiomyopathy, and miscellaneous etiologies compared to postcardiotomy CS as a referent. In conclusion, survival after ECMO initiation differs based on underlying cause of CS. Survival may be lower in older patients and those with early evidence of persistent hypoperfusion after initiation of ECMO for CS.