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Comparison of myelin water fraction from multiecho T2 decay curve and steady-state methods
Magnetic resonance in medicine, 2015-01, Vol.73 (1), p.223-232
Zhang, Jing
Kolind, Shannon H.
Laule, Cornelia
MacKay, Alex L.
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Zhang, Jing
Kolind, Shannon H.
Laule, Cornelia
MacKay, Alex L.
Titel
Comparison of myelin water fraction from multiecho T2 decay curve and steady-state methods
Ist Teil von
Magnetic resonance in medicine, 2015-01, Vol.73 (1), p.223-232
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
Purpose Myelin water fraction is conventionally measured from the T2 decay curve. Recently, a steady‐state approach entitled multicomponent‐driven equilibrium single pulse observation of T1/T2 (mcDESPOT) was employed for myelin water fraction mapping. However, no direct comparison between the established multiecho T2 relaxation method and mcDESPOT has been performed. Methods Gradient and spin echo (GRASE) acquired T2 decay curve and mcDESPOT measurements were acquired from 10 healthy volunteers using a 3T MRI. We compared myelin water fraction, transmit radio frequency field (B1), and T2's of intra‐ and extracellular water obtained from both methods. Results For all brain regions examined, myelin water fractions from mcDESPOT were significantly higher than those from multiecho GRASE. B1 maps were qualitatively similar between GRASE and mcDESPOT, but multicomponent T2 times were significantly different. To investigate the effect of exchange, mcDESPOT data were analyzed with and without exchange. When exchange was turned off, intra‐ and extracellular T2 times from mcDESPOT were roughly consistent with GRASE results; however, myelin water fractions derived from mcDESPOT were still significantly higher than those derived from GRASE. Conclusion Myelin water fraction values derived from mcDESPOT cannot be considered to be equivalent to those derived from T2 decay curve approaches. Magn Reson Med 73:223–232, 2015. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.25125
Titel-ID: cdi_proquest_miscellaneous_1728672888
Format
–
Schlagworte
Adult
,
Algorithms
,
Body Water - chemistry
,
Brain Chemistry
,
Echo-Planar Imaging - methods
,
Female
,
Humans
,
Image Interpretation, Computer-Assisted - methods
,
Male
,
mcDESPOT
,
Middle Aged
,
Molecular Imaging - methods
,
Myelin Sheath - chemistry
,
myelin water fraction
,
Nerve Fibers, Myelinated - chemistry
,
Reference Values
,
Reproducibility of Results
,
Sensitivity and Specificity
,
steady-state imaging
,
T2 relaxation
,
Tissue Distribution
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