Details

Autor(en) / Beteiligte

• Wu, Xiang
• Lin, Hua-Chen
• Li, Ming-Li
• Li, Lu-Lu
• Han, Zhi-Yong
• Gong, Liu-Zhu

Titel

Enantioselective 1,2-Difunctionalization of Dienes Enabled by Chiral Palladium Complex-Catalyzed Cascade Arylation/Allylic Alkylation Reaction

Ist Teil von

• Journal of the American Chemical Society, 2015-10, Vol.137 (42), p.13476-13479

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A Pd-catalyzed highly enantio­selective three-component coupling of 1,3-dienes with aryl iodines and sodium dialkyl malonates has been successfully established by using a H8-BINOL-based phosphor­amidite ligand. This reaction proceeded via a Pd-catalyzed cascade aryl­ation and asymmetric allylic alkyl­ation reaction, providing an efficient strategy for the enantio­selective 1,2-di­functional­ization of 1,3-dienes.