Details

Autor(en) / Beteiligte

• Zlotnikov-Klionsky, Yael
• Nathansohn-Levi, Bar
• Shezen, Elias
• Rosen, Chava
• Kagan, Sivan
• Bar-On, Liat
• Jung, Steffen
• Shifrut, Eric
• Reich-Zeliger, Shlomit
• Friedman, Nir
• Aharoni, Rina
• Arnon, Ruth
• Yifa, Oren
• Aronovich, Anna
• Reisner, Yair

Titel

Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity

Ist Teil von

• Immunity (Cambridge, Mass.), 2015-10, Vol.43 (4), p.776-787

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic syndrome. This phenotype was associated with an altered repertoire of T cells residing in adipose tissue and could be completely prevented by T cell depletion in vivo. A similar impact of perf-DCs on inflammatory T cells was also found in a well-defined model of multiple sclerosis, experimental autoimmune encephlalomyelitis (EAE). Thus, perf-DCs probably represent a regulatory cell subpopulation critical for protection from metabolic syndrome and autoimmunity. [Display omitted] •Mice lacking perforin+ DCs gain weight and exhibit features of metabolic syndrome•The onset of this phenotype can be accelerated upon feeding with high-fat diet•The phenotype can be completely prevented by T cell depletion in vivo•Similar impact on T cells by perf-DCs was found in a model of multiple sclerosis Perforin-positive dendritic cells (perf-DCs) represent a minor subpopulation of myeloid DCs. Based on selective ablation of perf-DCs in radiation chimera, Reisner and colleagues demonstrate that these cells control inflammatory T cells in steady state and play a regulatory role in metabolic syndrome and in experimental autoimmune encephalomyelitis.