Details

Autor(en) / Beteiligte

• Shew, Marcia L.
• Ermel, Aaron C.
• Tong, Yan
• Tu, Wanzhu
• Qadadri, Brahim
• Brown, Darron R.

Titel

Episodic detection of human papillomavirus within a longitudinal cohort of young women

Ist Teil von

• Journal of medical virology, 2015-12, Vol.87 (12), p.2122-2129

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Redetection of a type‐specific human papillomavirus (HPV) infection may represent reinfection. However, a growing body of literature suggests that reactivation of HPV is common and that episodic detection of a HPV infection may represent reactivation of a persistent virus. A cohort of prospectively followed adolescent women (N = 150), ages 14–17, was observed on average 6.4 years. The authors describe the redetection of 37 HPV types and associated factors of redetection of high‐risk (HR) and low‐risk (LR) types using Cox proportional hazard models. Of 1,248 HPV type‐specific infections, 286 (22.9%) were associated with redetection after apparent clearance. Chlamydia infections (HR = 1.99 [95%CI, 1.15–3.49]) and non‐condom use (HR = 1.1 [95%CI, 1.04–1.99]) were associated with increased redetection of HR‐HPV infections. Oral contraceptive pills (HR = 2.73 [95%CI, 1.52–4.90]) and number of sexual partners (HR = 1.44 [95%CI, 1.04–1.99]) were associated with increased redetection of LR‐HPV infections. Episodic detection of HPV is common for HR‐ and LR‐HPV types. This finding and identified factors or redetection have clinical implications and enhances the understanding of HPV natural history. J. Med. Virol. 87:2122–2129, 2015. © 2015 Wiley Periodicals, Inc.