Details

Autor(en) / Beteiligte

• Gašparović, Iva
• Čizmarević, Nada Starčević
• Lovrečić, Luca
• Perković, Olivio
• Lavtar, Polona
• Sepčić, Juraj
• Jazbec, Saša Šega
• Kapović, Miljenko
• Peterlin, Borut
• Ristić, Smiljana

Titel

MMP-2 −1575G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?

Ist Teil von

• Journal of neuroimmunology, 2015-09, Vol.286, p.13-15

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and MMP-9 in serum and cerebrospinal fluid of multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. Optic neuritis (ON) is a common symptom of both disorders. Here we investigated the impacts of MMP-2 −1575G/A and MMP-9 −1562 C/T gene polymorphisms on disease phenotype in 100 MS patients with ON as a first symptom and 376 MS patients with other initial symptomatology. The MMP-2 −1575G/A polymorphism led to a 5-year-earlier age of disease onset in MS patients with ON as a first symptom (p=0.009). •MMP-2 and MMP-9 polymorphisms were evaluated in patients with and without ON at MS onset.•SNPs within MMP2 and MMP9 are not associated with ON risk or disease severity in MS patients.•MMP-2 −1575G/A polymorphism led to a 5-year-earlier MS onset among patients with ON.