Details

Autor(en) / Beteiligte

• Chiari, Rita
• Metro, Giulio
• Iacono, Daniela
• Bellezza, Guido
• Rebonato, Alberto
• Dubini, Alessandra
• Sperduti, Isabella
• Bennati, Chiara
• Paglialunga, Luca
• Burgio, Marco Angelo
• Baglivo, Sara
• Giusti, Raffaele
• Minotti, Vincenzo
• Delmonte, Angelo
• Crinò, Lucio

Titel

Clinical impact of sequential treatment with ALK-TKIs in patients with advanced ALK -positive non-small cell lung cancer: Results of a multicenter analysis

Ist Teil von

• Lung cancer (Amsterdam, Netherlands), 2015-11, Vol.90 (2), p.255-260

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights • The outcome of 69 ALK -positive NSCLCs treated with a 1st ALK-TKI was investigated. • Upon failure of a 1st ALK-TKI, 22 patients received a 2nd ALK-TKI. • 7 and 8 NSCLCs received the same ALK-TKI and other systemic therapies, respectively. • ORR and PFS on a 2nd ALK-TKI were 86.4% and 7 months, respectively. • Post-progression survival favored both the 2nd ALK-TKI and beyond progression group.