Details

Autor(en) / Beteiligte

• Godar, S
• Horejsi, V
• Weidle, U H
• Binder, B R
• Hansmann, C
• Stockinger, H

Titel

M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor- beta 1

Ist Teil von

• European journal of immunology, 1999-03, Vol.29 (3), p.1004-1013

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Transforming growth factor- beta 1 (TGF- beta 1) is a critical cytokine for cell proliferation and differentiation. It is secreted by many cells in a latent pro-form (LTGF- beta 1) from which biologically active TGF- beta 1 is released by an in vivo mechanism that is not known. Here we show that the mannose-6-phosphate/insulin-like growth factor II-receptor (M6P/IGFII-R), which binds LTGF- beta 1, complexes with urokinase (plasminogen activator)-receptor (uPA-R) on the surface of human monocytes and directly binds plasminogen (Plg). Plasmin generated from Plg in the complex mediates release of TGF- beta 1 when M6P/IGFII-R is associated with uPA-R. Thus, this interaction of M6P/IGFII-R and uPA-R suggests a potential mechanism for the generation of TGF- beta 1 by cells.