Details

Autor(en) / Beteiligte

• Sun, Da-wei
• Zhang, Ying-yi
• Sun, Xiao-dong
• Chen, Yu-guo
• Qiu, Wei
• Ji, Min
• Lv, Guo-yue

Titel

Prognostic value of cytokeratin 19 in hepatocellular carcinoma: A meta-analysis

Ist Teil von

• Clinica chimica acta, 2015-08, Vol.448, p.161-169

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Although many studies have investigated the relationship between cytokeratin 19 (CK-19) and hepatocellular carcinoma (HCC), the prognostic value of CK-19 in HCC remains inconclusive. Eligible studies were sought in PubMed, Embase, Web of Science, Cochrane Library and Wanfang databases. Pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated. 17 studies with 2943 patients were included in this meta-analysis. Meta-analysis results showed that CK-19 over-expression was significantly associated with overall survival (OS) (HR=1.60, 95% CI: 1.32–1.93, univariate analysis; HR=2.25, 95% CI: 1.79–2.83, multivariate analysis) and disease-free survival (DFS) (HR=1.68, 95% CI: 1.35–2.10, univariate analysis; HR=1.97, 95% CI: 1.54–2.53, multivariate analysis). Meanwhile, CK-19 over-expression was also correlated with decreased 1-year OS rate (OR=0.32, 95% CI: 0.21–0.50), 5-year OS rate (OR=0.44, 95% CI: 0.14–0.87) and 1-year DFS rate (OR=0.51, 95% CI: 0.34–0.76), but not with 5-year DFS rate (OR=0.62, 95% CI: 0.35–1.10). These results suggested that CK-19 over-expression was significantly associated with poor survival rate and early tumor recurrence rate in HCC patients. CK-19 can serve as an indicator of poor prognosis as well as a novel target for treatment in HCC. •A meta-analysis investigated the prognostic value of CK-19 on HCC patients.•Seventeen studies with 2943 patients were included in this meta-analysis.•CK-19 over-expression can serve as an indicator of poor prognosis in HCC.•CK-19 may become a potential novel target for treatment of HCC patients.•More studies are needed to investigate the value of serum CK-19 in HCC.