Details

Autor(en) / Beteiligte

• Brent, Jeffrey
• McMartin, Kenneth
• Phillips, Scott
• Burkhart, Keith K
• Donovan, J. Ward
• Wells, Melanie
• Kulig, Ken

Titel

Fomepizole for the Treatment of Ethylene Glycol Poisoning

Ist Teil von

• The New England journal of medicine, 1999-03, Vol.340 (11), p.832-838

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1999

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Ethylene glycol poisoning may cause severe morbidity and death. 1 Though not toxic itself, ethylene glycol is converted by alcohol dehydrogenase to active metabolites 1 , 2 (Figure 1) that cause metabolic acidosis, renal failure, hypocalcemia, oxaluria, damage to the central nervous system and cranial nerves, and cardiovascular instability. 3 Standard treatments for ethylene glycol poisoning are hemodialysis and inhibition of alcohol dehydrogenase, 1 , 4 the latter by the intravenous or oral administration of high (intoxicating) doses of ethanol. The accepted target plasma ethanol concentration is 100 to 125 mg per deciliter (21.7 to 27.1 mmol per liter). 1 Since patients are treated with large doses . . .