Details

Autor(en) / Beteiligte

• Sclafani, Anthony
• Azzara, Anthony V
• Touzani, Khalid
• Grigson, Patricia Sue
• Norgren, Ralph

Titel

Parabrachial Nucleus Lesions Block Taste and Attenuate Flavor Preference and Aversion Conditioning in Rats

Ist Teil von

• Behavioral neuroscience, 2001-08, Vol.115 (4), p.920-933

Ort / Verlag

Washington, DC: American Psychological Association

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• Rats with ibotenic acid lesions of the parabrachial nucleus (PBN) failed to learn a taste aversion induced by lithium chloride (LiCl) toxicosis. The same rats also did not learn to prefer a taste that was paired with intragastric (IG) carbohydrate infusions during 22 hr/day trials. The PBN-lesioned rats did learn to prefer a flavor (odor + taste) paired with the IG carbohydrate infusions over a different flavor paired with IG water. The PBN-lesioned rats also learned to avoid a flavor paired with IG LiCl infusions during 22 hr/day trials. The flavor preference and aversion, however, were less pronounced than those displayed by control rats. These data indicate that the PBN is essential for forming orosensory-viscerosensory associations when taste is the primary cue but is less critical when more complex flavor cues are available.