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The Epidemiology of Nonsurgical Hypoparathyroidism in Denmark: A Nationwide Case Finding Study
Journal of bone and mineral research, 2015-09, Vol.30 (9), p.1738-1744
Underbjerg, Line
Sikjaer, Tanja
Mosekilde, Leif
Rejnmark, Lars
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Underbjerg, Line
Sikjaer, Tanja
Mosekilde, Leif
Rejnmark, Lars
Titel
The Epidemiology of Nonsurgical Hypoparathyroidism in Denmark: A Nationwide Case Finding Study
Ist Teil von
Journal of bone and mineral research, 2015-09, Vol.30 (9), p.1738-1744
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
ABSTRACT Nonsurgical hypoparathyroidism (HypoPT) is a rare disorder most often caused by mutations in different genes. It is characterized by hypocalcaemia with inappropriately low PTH levels. Knowledge about this group of patients, including their mortality and morbidity, is very sparse. The aim was to identify all patients diagnosed with nonsurgical HypoPT in Denmark and assess their mortality and risk of complications. Through registers and review of individual patient hospital charts we identified all patients diagnosed with nonsurgical HypoPT in Denmark between 1977 and 2012. We assessed their mortality and morbidity by comparing them with a group of age‐ and gender‐matched population‐based controls. We identified a total of 180 patients with nonsurgical HypoPT among whom 123 (68%) were alive at the date of follow‐up (prevalence of 2.3/100,000 inhabitants). Compared with controls, mortality was not increased, but patients had a significantly increased risk of renal insufficiency (hazard ratio [HR] 6.01), cardiovascular diseases (HR 1.91), neuropsychiatric complications (HR 2.45), infections (HR 1.94), seizures (HR 10.05), cataract (HR 4.21), and fractures at the upper extremities (HR 1.93). In contrast patients had significantly reduced risk of malignant diseases (HR 0.44). In conclusion, nonsurgical HypoPT is a rare disease associated with a number of complications that should be considered when taking care of these patients. © 2015 American Society for Bone and Mineral Research.
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.2501
Titel-ID: cdi_proquest_miscellaneous_1722181006
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
Aged, 80 and over
,
Cardiovascular diseases
,
Cardiovascular Diseases - complications
,
Case-Control Studies
,
Cataract - complications
,
Child
,
Child, Preschool
,
Data Collection
,
Denmark - epidemiology
,
EPIDEMIOLOGY
,
Female
,
Follow-Up Studies
,
Fractures
,
Fractures, Bone - complications
,
Fractures, Bone - epidemiology
,
Humans
,
Hypocalcemia
,
Hypocalcemia - complications
,
Hypocalcemia - epidemiology
,
Hypoparathyroidism
,
Hypoparathyroidism - complications
,
Hypoparathyroidism - epidemiology
,
Infant
,
Infant, Newborn
,
Male
,
Mental disorders
,
Mental Disorders - complications
,
Middle Aged
,
Morbidity
,
Mortality
,
Mutation
,
Neoplasms - complications
,
OTHER THERAPEUTICS
,
Parathyroid hormone
,
PARATHYROID‐RELATED DISORDERS
,
Proportional Hazards Models
,
Registries
,
Renal insufficiency
,
Renal Insufficiency - complications
,
Retrospective Studies
,
Seizures
,
Seizures - complications
,
Young Adult
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