Details

Autor(en) / Beteiligte

• Yan, Guobing
• Borah, Arun Jyoti
• Wang, Lianggui
• Yang, Minghua

Titel

Recent Advances in Transition Metal-Catalyzed Methylation Reactions

Ist Teil von

• Advanced synthesis & catalysis, 2015-05, Vol.357 (7), p.1333-1350

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2015

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal‐catalyzed cross‐coupling reactions. In this review, recent advances in this area are summarized, mainly including C‐methylation, N‐methylation and O‐methylation. The respective reaction mechanisms are also discussed.