Details

Autor(en) / Beteiligte

• BENTIRES-ALJ, M
• HELLIN, A.-C
• AMEYAR, M
• CHOUAIB, S
• MERVILLE, M.-P
• BOURS, V

Titel

Stable inhibition of nuclear factor κB in cancer cells does not increase sensitivity to cytotoxic drugs

Ist Teil von

• Cancer research (Chicago, Ill.), 1999-02, Vol.59 (4), p.811-815

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

1999

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Several reports indicated that nuclear factor Kappa B (NF- Kappa B) activation by cytokines, cytotoxic drugs, or ionizing radiation protects cells against apoptosis. Therefore, we investigated the consequence of NF- Kappa B inhibition on the efficiency of antineoplastic agents. HPB, HCT116, MCF7, and OVCAR-3 cells stably expressing a dominant negative I Kappa B alpha inhibitor showed a decreased NF- Kappa B activation following treatment with tumor necrosis factor alpha and various chemotherapeutic agents. However, there was no difference in survival between parental cells and cells expressing mutated I Kappa B alpha . These studies suggest that, at least in these cell lines, stable NF- Kappa B inhibition did not modify the response to cytotoxic drugs.