Details

Autor(en) / Beteiligte

• Wang, Di
• Wang, Wei
• Zhou, Yulin
• Wang, Juan
• Jia, Dongxu
• Wong, Hei Kiu
• Zhang, Zhang-Jin

Titel

Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model

Ist Teil von

• Neuroscience letters, 2015-10, Vol.606, p.60-65

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• •The hyperprolactinemia rat model is established successfully.•The anti-hyperprolactinemia activity of Peony-Glycyrrhiza Decoction is confirmed.•PGD modulates the expression of DRD2 and DAT to suppress the prolactin level.•PGD restores serum progesterone level to suppress the hyper-level of prolactin.•Peony play a more important role in PGD-mediated anti-hyperprolactinemia effect. Clinical trials have demonstrated the beneficial effects of Peony-Glycyrrhiza Decoction (PGD) in alleviating antipsychotic-induced hyperprolactinemia (hyperPRL) in schizophrenic patients. In previous experiment, PGD suppressed prolactin (PRL) level in MMQ cells, involving modulating the expression of D2 receptor (DRD2) and dopamine transporter (DAT). In the present study, hyperPRL female rat model induced by dopamine blocker metoclopramide (MCP) was applied to further confirm the anti-hyperpPRL activity of PGD and underlying mechanism. In MCP-induced hyperPRL rats, the elevated serum PRL level was significantly suppressed by either PGD (2.5–10g/kg) or bromocriptine (BMT) (0.6mg/kg) administration for 14 days. However, in MCP-induced rats, only PGD restored the under-expressed serum progesterone (P) to control level. Both PGD and BMT administration restore the under-expression of DRD2, DAT and TH resulted from MCP in pituitary gland and hypothalamus. Compared to untreated group, hyperPRL animals had a marked reduction on DRD2 and DAT expression in the arcuate nucleus. PGD (10g/kg) and BMT (0.6mg/kg) treatment significant reversed the expression of DRD2 and DAT. Collectively, the anti-hyperPRL activity of PGD associates with the modulation of dopaminergic neuronal system and the restoration of serum progesterone level. Our finding supports PGD as an effective agent against hyperPRL.