Cancer letters, 2015-12, Vol.369 (1), p.58-66
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Identification of miRNomes in human stomach and gastric carcinoma reveals miR-133b/a-3p as therapeutic target for gastric cancer
- Ist Teil von
- Cancer letters, 2015-12, Vol.369 (1), p.58-66
- Ort / Verlag
- Ireland: Elsevier B.V
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Heatmap analysis of the miRNomes was performed across TCGA datasets. • miR-133 is downregulated in gastric cancer. • Downregulation of miR-133 is mediated by histone modification. • miR-133 promotes gastric cancer cell apoptosis by targeting Mcl-1 and Bcl-xL. • Anti-tumor effect of miR-133 was verified in xenograft mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2015.06.028Titel-ID: cdi_proquest_miscellaneous_1721350210
- Format
- –
- Schlagworte
- 3' Untranslated Regions, Animals, Apoptosis, Base Sequence, bcl-X Protein - genetics, bcl-X Protein - metabolism, Binding Sites, Cell growth, Cell Line, Tumor, Cell Proliferation, Chemotherapy, Epigenetics, Experiments, Female, Gastric cancer, Gene Expression, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Genetic Therapy, HEK293 Cells, Hematology, Oncology and Palliative Medicine, Histones - metabolism, Hospitals, Humans, Mice, Nude, microRNA, MicroRNAs - genetics, MicroRNAs - metabolism, miRNomes, Mortality, Myeloid Cell Leukemia Sequence 1 Protein - genetics, Myeloid Cell Leukemia Sequence 1 Protein - metabolism, Neoplasm Transplantation, RNA Interference, Rodents, Stomach Neoplasms - genetics, Stomach Neoplasms - metabolism, Stomach Neoplasms - pathology, Studies, Therapy, Tumor Burden, Tumors