Brain research, 1999-04, Vol.824 (1), p.125-132
1999
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Details
- Autor(en) / Beteiligte
- Titel
- Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid
- Ist Teil von
- Brain research, 1999-04, Vol.824 (1), p.125-132
- Ort / Verlag
- London: Elsevier B.V
- Erscheinungsjahr
- 1999
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. ×2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyrus sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-8993eISSN: 1872-6240DOI: 10.1016/S0006-8993(99)01155-5Titel-ID: cdi_proquest_miscellaneous_17195282
- Format
- –
- Schlagworte
- Activator protein-1, Animals, Biological and medical sciences, Dextromethorphan, Dextromethorphan - pharmacology, DNA - metabolism, Excitatory Amino Acid Antagonists - pharmacology, Fos-related antigen, Hippocampus, Hippocampus - drug effects, Hippocampus - metabolism, Kainic acid, Kainic Acid - pharmacology, Male, Medical sciences, Neuropharmacology, Neuroprotection, Neuroprotective agent, Pharmacology. Drug treatments, Proto-Oncogene Proteins c-fos - metabolism, Rats, Rats, Sprague-Dawley, Time Factors, Tissue Distribution - physiology, Transcription Factor AP-1 - metabolism