Details

Autor(en) / Beteiligte

• Jessen, Kristjan R.
• Mirsky, Rhona
• Arthur-Farraj, Peter

Titel

The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming

Ist Teil von

• Developmental cell, 2015-09, Vol.34 (6), p.613-620

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• It is becoming clear that a radical change of cell identity of differentiated cells in vivo, triggered by injury or other adversity, provides an essential route to recovery for many different mammalian tissues. This process, which we term adaptive cellular reprogramming, promotes regeneration in one of two ways: by providing a transient class of repair cells or by directly replacing cells lost during tissue damage. Controlling adaptive changes in cell fate in vivo in order to promote the body’s own cell therapy, particularly by pharmacology rather than genetics, is likely to become an increasingly active area of future work. In this Review article, Jessen and colleagues discuss how changes in cell identity in vivo, in response to injury, can promote regeneration and repair via a process they term “adaptive cellular reprogramming.” They discuss examples of this process in different tissues, including skin, heart and the nervous system.