Details

Autor(en) / Beteiligte

• Birdir, Cahit
• Janssen, Katharina
• Stanescu, Anca Daniela
• Enekwe, Antje
• Kasimir-Bauer, Sabine
• Gellhaus, Alexandra
• Kimmig, Rainer
• Köninger, Angela

Titel

Maternal serum copeptin, MR-proANP and procalcitonin levels at 11–13 weeks gestation in the prediction of preeclampsia

Ist Teil von

• Archives of gynecology and obstetrics, 2015-11, Vol.292 (5), p.1033-1042

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose We investigated the potential value of maternal serum copeptin, midregional proatrial natriuretic peptide (MR-proANP) and Procalcitonin (PCT) levels at 11–13 weeks’ gestation in the prediction of preeclampsia (PE) in a case–control study. Materials and methods Maternal serum concentration of copeptin, MR-proANP and PCT were measured at 11–13 weeks’ gestation in cases of PE ( n  = 35) and controls ( n  = 100). The PE group was divided into early-onset PE (EO-PE) and late-onset PE (LO-PE). From the regression model, the value in each case and control was expressed as a multiple of the expected median (MoM). The Mann–Whitney test was used to determine the significance of differences in the median MoM in each outcome group from that in the controls. Results In the PE group, compared to controls, maternal serum concentrations of copeptin, MR-proANP and PCT were not significantly different. Conclusion The maternal serum copeptin, MR-proANP and PCT levels are higher in EO-PE and LO-PE patients, but the difference is not significant. Thus, their levels in first trimester are not proven to be effective markers to screen for PE.