Insect biochemistry and molecular biology, 2006-04, Vol.36 (4), p.310-321
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Iron metabolism in insect disease vectors: Mining the Anopheles gambiae translated protein database
- Ist Teil von
- Insect biochemistry and molecular biology, 2006-04, Vol.36 (4), p.310-321
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- All animals require iron for survival. This requirement reflects the role of this mineral as a cofactor of numerous proteins. However, under physiological conditions, Fe 2+ oxidizes to Fe 3+ encouraging the formation of toxic free radicals. In mammals, the potential for oxidative damage from iron is minimized by binding iron to proteins. Mammalian iron metabolism is complex and numerous proteins are involved in iron absorption, transport, uptake and utilization. We have analyzed the Anopheles gambiae translated protein database for candidates that show identity to proteins involved in mammalian iron metabolism (Holt et al., 2002. The genome sequence of the malaria mosquito Anopheles gambiae. Science 298, 129–149). Our results indicate that proteins involved in iron absorption and intracellular iron utilization are, for the most part, conserved in A. gambiae. In contrast, proteins involved in the pathways of iron export from the gut, transport in hemolymph and uptake at peripheral tissues in mosquitos differ from those for mammals.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0965-1748eISSN: 1879-0240DOI: 10.1016/j.ibmb.2006.01.006Titel-ID: cdi_proquest_miscellaneous_17171239
- Format
- –
- Schlagworte
- amino acid sequences, Animals, Anopheles, Anopheles - genetics, Anopheles - metabolism, Anopheles gambiae, Antimicrobial Cationic Peptides - physiology, binding proteins, Biological Transport - physiology, Culicidae, data mining, Databases, Protein, Hepcidins, Humans, Insect disease vector, insect proteins, Insect Proteins - chemistry, Insect Proteins - genetics, Insect Proteins - physiology, insect vectors, Insect Vectors - genetics, Insect Vectors - metabolism, Intestines - metabolism, Iron, Iron - metabolism, iron-binding proteins, Iron-Binding Proteins - chemistry, Iron-Binding Proteins - genetics, Iron-Binding Proteins - physiology, Iron-Regulatory Proteins - physiology, Membrane Proteins - physiology, mineral metabolism, Models, Biological, Oxidoreductases - physiology, proteome, proteomics, Sequence Analysis, Protein, Sequence Homology, Amino Acid, translation (genetics)