Surgical oncology, 2015-09, Vol.24 (3), p.276-283
2015
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- An overview of triple negative breast cancer for surgical oncologists
- Ist Teil von
- Surgical oncology, 2015-09, Vol.24 (3), p.276-283
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Abstract Triple negative breast cancers (TNBCs) represent a distinct subgroup of breast cancers with an immunohistochemical phenotype that is negative for oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2). The aim of this article is to provide a broad overview of recent developments in the diagnosis and management of TNBC for surgical oncologists. This overview discusses the subtypes of TNBC and the relationship between this type of breast cancer and the BRCA1 gene. In addition, the article explores recent advances in the treatment of TNBC from a surgical, radiation, and medical oncology point of view. Lastly, evolving therapeutic strategies that have potential to enhance outcomes for patients with TNBC are also discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-7404eISSN: 1879-3320DOI: 10.1016/j.suronc.2015.06.007Titel-ID: cdi_proquest_miscellaneous_1716939849
- Format
- –
- Schlagworte
- Androgens, Angiogenesis, Apoptosis, Breast cancer, Breast surgery oncology, Cancer therapies, Cell cycle, Chemotherapy, Conflicts of interest, Epidemiology, Epidermal growth factor, Female, Gene expression, Hematology, Oncology and Palliative Medicine, Humans, Investigations, Kinases, Medical prognosis, Metastasis, Molecular biology, Morphology, Mutation, Prognosis, Receptor, ErbB-2 - metabolism, Receptors, Estrogen - metabolism, Receptors, Progesterone - metabolism, Review, Signal transduction, Surgery, Triple negative breast cancer, Triple Negative Breast Neoplasms - diagnosis, Triple Negative Breast Neoplasms - metabolism, Triple Negative Breast Neoplasms - therapy, Tumors, Womens health