Details

Autor(en) / Beteiligte

• Olorunsola, Olufoladare G., MD
• Kohi, Maureen P., MD
• Behr, Spencer C., MD
• Kolli, Pallav K., MD
• Taylor, Andrew G., MD, PhD
• Tong, Ricky T., MD, PhD
• LaBerge, Jeanne M., MD
• Kerlan, Robert K., MD
• Fidelman, Nicholas, MD

Titel

Imaging Predictors of Elevated Lung Shunt Fraction in Patients Being Considered for Yttrium-90 Radioembolization

Ist Teil von

• Journal of vascular and interventional radiology, 2015-10, Vol.26 (10), p.1472-1478

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Purpose To identify imaging findings associated with elevated lung shunt fraction (LSF) in patients being considered for yttrium-90 (90 Y) radioembolization. Materials and Methods During the period 2009–2014, 152 consecutive patients underwent planning hepatic arteriography with technetium-99m (99m Tc) macroaggregated albumin (MAA) injection. Computed tomography (CT) or magnetic resonance imaging performed before the procedure for each patient was assessed for hepatic vein (HV) tumor thrombus or occlusion from external compression by tumor. When imaging was a multiphase CT scan (117 patients), the arterial phase was evaluated for evidence of early HV opacification (relative to unaffected HVs), indicating hepatic venous shunting. These factors were correlated with LSF determined by99m Tc-MAA imaging. Results Median LSF was 6.7% (range, < 0.1%–71%), significantly higher for HCC (8.0% vs 6.3% for other tumors, P = .048). Larger tumor size was associated with higher LSF in univariate analysis ( P = .001). There was high interobserver agreement for determining hepatic venous shunting (97%, κ = 0.847), which was associated with higher LSF ( P < .001; 78% sensitivity, 93% specificity). Of 5 cases of HV tumor thrombus, all had high (> 20%) LSF ( P < .001). HV occlusion was also associated with higher LSF ( P = .039). Multivariate analysis confirmed that early HV opacification and either HV tumor thrombus or occlusion were associated with higher LSF. Conclusions Early HV opacification and HV tumor thrombus or occlusion on cross-sectional imaging performed before radioembolization are associated with elevated LSF, which may contraindicate or limit the dose delivered in90 Y radioembolization. This information could be helpful during patient counseling for anticipating the most appropriate mode of liver-directed therapy.