Details

Autor(en) / Beteiligte

• Quintanilla, Jorge G., MSEng
• Moreno, Javier, MD, PhD
• Archondo, Tamara, MD
• Usandizaga, Elena, MSEng
• Molina-Morúa, Roberto, MSEng
• Rodríguez-Bobada, Cruz, VMD, PhD
• González, Pablo, VMD
• García-Torrent, María Jesús, PhD
• Filgueiras-Rama, David, MD, PhD
• Pérez-Castellano, Nicasio, MD, PhD
• Macaya, Carlos, MD, PhD
• Pérez-Villacastín, Julián, MD, PhD

Titel

Increased intraventricular pressures are as harmful as the electrophysiological substrate of heart failure in favoring sustained reentry in the swine heart

Ist Teil von

• Heart rhythm, 2015-10, Vol.12 (10), p.2172-2183

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Background Heart failure (HF) electrophysiological remodeling (HF-ER) often includes the effect of chronically increased intraventricular pressures (IVPs) and promotes ventricular tachycardia/ventricular fibrillation (VT/VF). In addition, acutely increased IVPs have been associated with a higher rate of VT/VF episodes in chronic HF. Objective We hypothesized that increased IVPs and/or an ionic-imbalanced (acidified), catecholamine-rich (adrenergic) milieu (AA milieu) may contribute as much as HF-ER to the substrate for reentry in HF. We used a porcine model of tachycardiomyopathy and evaluated the individual/combined contributions of (1) increased IVPs, (2) HF-ER, and (3) an AA milieu. Methods HF-ER was induced in 7 pigs by rapid pacing. Seven pigs were used as controls. Hearts were isolated and Langendorff perfused. Programmed ventricular stimulation was conducted under low or increased IVP and normal/AA milieu (4 combinations). Epicardial optical mapping was used to quantify conduction velocity (CV), action potential duration (APD), and dispersion of repolarization (DoR). Results HF-ER decreased CV (−34%; P = .002) and increased APD (11%; P = .024) and DoR (21%; P = .007). Increased IVP amplified DoR (36%; P < .001) and decreased CV (−17%; P = .001) and APD (−8%; P < .001). The AA milieu consistently modified only APD (−9%; P < .001) and led to amplified inter-/intra-subject heterogeneity. Increased IVP similarly raised the odds of inducing sustained VT/VF as the presence of HF-ER (>6-fold). Conclusion By magnifying DoR, decreasing CV, and shortening APD, increased IVP was as harmful as HF-ER in favoring the substrate for sustained reentry in this model. The AA milieu contributed to a much lesser extent. Thus, a stricter control of IVP might be postulated as a useful add-on antiarrhythmic strategy in HF.