Details

Autor(en) / Beteiligte

• Diamond, Michael P
• Legro, Richard S
• Coutifaris, Christos
• Alvero, Ruben
• Robinson, Randal D
• Casson, Peter
• Christman, Gregory M
• Ager, Joel
• Huang, Hao
• Hansen, Karl R
• Baker, Valerie
• Usadi, Rebecca
• Seungdamrong, Aimee
• Bates, G. Wright
• Rosen, R. Mitchell
• Haisenleder, Daniel
• Krawetz, Stephen A
• Barnhart, Kurt
• Trussell, J.C
• Ohl, Dana
• Jin, Yufeng
• Santoro, Nanette
• Eisenberg, Esther
• Zhang, Heping

Titel

Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility

Ist Teil von

• The New England journal of medicine, 2015-09, Vol.373 (13), p.1230-1240

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• This trial compared letrozole with gonadotropin or clomiphene in women with unexplained infertility. Letrozole resulted in a significantly lower frequency of multiple gestation, but also a lower frequency of live birth, as compared with gonadotropin but not as compared with clomiphene. Therapeutic options for couples with unexplained infertility include assisted reproductive technologies, such as in vitro fertilization (IVF) and embryo transfer, and empirical ovarian stimulation combined with intrauterine insemination. The high cost and limited insurance coverage of IVF in all but a few locales in the United States make it an unattainable option for most infertile couples. 1 Empirical ovarian stimulation has been thought to promote childbearing by increasing the number of ova ovulated, as well as possibly by enhancing implantation, placentation, or both through hormonal effects on the endometrium. 2 – 4 However, empirical ovarian stimulation (with clomiphene or particularly with gonadotropin) is . . .