Details

Autor(en) / Beteiligte

• Zhou, Wei
• Fan, Mengyang
• Yin, Junli
• Jiang, Yongwen
• Ma, Dawei

Titel

CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines

Ist Teil von

• Journal of the American Chemical Society, 2015-09, Vol.137 (37), p.11942-11945

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• A class of oxalic diamides are found to be effective ligands for promoting CuI-catalyzed aryl amination with less reactive (hetero)­aryl chlorides. The reaction proceeds at 120 °C with K3PO4 as the base in DMSO to afford a wide range of (hetero)­aryl amines in good to excellent yields. The bis­(N-aryl) substituted oxalamides are superior ligands to N-aryl-N′-alkyl substituted or bis­(N-alkyl) substituted oxalamides. Both the electronic nature and the steric property of the aromatic rings in ligands are important for their efficiency.