Details

Autor(en) / Beteiligte

• Pialoux, Gilles
• Raffi, François
• Brun-Vezinet, Françoise
• Meiffrédy, Vincent
• Flandre, Philippe
• Gastaut, Jean-Albert
• Dellamonica, Pierre
• Yeni, Patrick
• Delfraissy, Jean-François
• Aboulker, Jean-Pierre

Titel

A Randomized Trial of Three Maintenance Regimens Given after Three Months of Induction Therapy with Zidovudine, Lamivudine, and Indinavir in Previously Untreated HIV-1–Infected Patients

Ist Teil von

• The New England journal of medicine, 1998-10, Vol.339 (18), p.1269-1276

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1998

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Treatment of human immunodeficiency virus type 1 (HIV-1) infection with two nucleoside analogues plus a protease inhibitor is aimed at reducing plasma viral titers and keeping them below the detection limit and represents the current standard of antiretroviral therapy. 1 – 3 The combination of zidovudine, lamivudine, and indinavir reduces plasma HIV-1 RNA levels to below 500 copies per milliliter for up to two years in more than 80 percent of HIV-1–infected patients. 4 , 5 It is hoped that this sustained reduction in plasma HIV-1 RNA levels will translate into immune reconstitution, delayed progression to the acquired immunodeficiency syndrome (AIDS), and longer survival. . . .