Details

Autor(en) / Beteiligte

• Somvanshi, Pramod R.
• Patel, Anilkumar K.
• Bhartiya, Sharad
• Venkatesh, K. V.

Titel

Implementation of integral feedback control in biological systems

Ist Teil von

• Wiley interdisciplinary reviews. Mechanisms of disease, 2015-09, Vol.7 (5), p.301-316

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Integral control design ensures that a key variable in a system is tightly maintained within acceptable levels. This approach has been widely used in engineering systems to ensure offset free operation in the presence of perturbations. Several biological systems employ such an integral control design to regulate cellular processes. An integral control design motif requires a negative feedback and an integrating process in the network loop. This review describes several biological systems, ranging from bacteria to higher organisms in which the presence of integral control principle has been hypothesized. The review highlights that in addition to the negative feedback, occurrence of zero‐order kinetics in the process is a key element to realize the integral control strategy. Although the integral control motif is common to these systems, the mechanisms involved in achieving it are highly specific and can be incorporated at the level of signaling, metabolism, or at the phenotypic levels. WIREs Syst Biol Med 2015, 7:301–316. doi: 10.1002/wsbm.1307 This article is categorized under: Biological Mechanisms > Cell Signaling Analytical and Computational Methods > Dynamical Methods Physiology > Organismal Responses to Environment