Details

Autor(en) / Beteiligte

• Izuhara, Masayasu
• Ono, Koh
• Shiomi, Hiroki
• Morimoto, Takeshi
• Furukawa, Yutaka
• Nakagawa, Yoshihisa
• Shizuta, Satoshi
• Tada, Tomohisa
• Tazaki, Junichi
• Horie, Takahiro
• Kuwabara, Yasuhide
• Baba, Osamu
• Nishino, Tomohiro
• Kita, Toru
• Kimura, Takeshi

Titel

High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: A report from the CREDO-Kyoto registry cohort-2

Ist Teil von

• Atherosclerosis, 2015-10, Vol.242 (2), p.632-638

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objective To determine whether low HDL-C is a risk factor for adverse cardiovascular events in patients with known CAD. Methods We evaluated 10,391 patients who underwent PCI from January 2005 to December 2007. In total, 3838 (36.9%) patients had low HDL-C (HDL-C <40 mg/dL in males and <50 mg/dL in females) and 6553 (63.1%) patients had normal HDL-C based on measurements on admission. Results The unadjusted 5-year incidence of major adverse cardiac events (MACE: composite of cardiovascular death, myocardial infarction or stroke) was significantly higher in the low HDL-C group than in the normal HDL-C group (17.6% vs. 14.0%, P < 0.0001). However, after adjusting for confounders, low HDL-C was not associated with a higher risk of MACE (adjusted hazard ratio [HR] 1.07, 95% confidence interval (CI) 0.97–1.19; P = 0.19). There was no significant interaction between the effect of low HDL-C on MACE and several subgroup factors including age, sex, clinical presentation of CAD, statins use, serum low-density lipoprotein cholesterol level, and serum triglycerides level. Conclusion Low HDL-C, as compared with normal HDL-C, was not associated with higher 5-year risk of MACE in patients who underwent PCI.