Details

Autor(en) / Beteiligte

• Kavoussi, Shahryar K., M.D., M.P.H
• Odenwald, Kate C., M.S.N., R.N., A.C.N.P.-B.C
• Boehnlein, Lynn M., B.S
• Summers-Colquitt, Roxanne B., M.S
• Pool, Thomas B., Ph.D
• Swain, Jason E., Ph.D
• Jones, Jeffrey M., Ph.D
• Lindstrom, Mary J., Ph.D
• Lebovic, Dan I., M.D

Titel

Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng/mL versus 1–4 ng/mL

Ist Teil von

• Fertility and sterility, 2015-09, Vol.104 (3), p.633-636

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To determine whether antimüllerian hormone (AMH) levels predict the availability of good-quality supernumerary blastocysts for cryopreservation. Design Retrospective study. Setting Two fertility centers. Patient(s) First fresh IVF cycles (n = 247) grouped as follows: 40 women <35 year old with AMH <1 ng/mL and 77 women with AMH 1–4 ng/mL; 62 women ≥35 year old with AMH <1 ng/mL, and 68 women with AMH 1–4 ng/mL. Intervention(s) AMH level measured before IVF with ovarian stimulation protocols based on patient age and AMH level, including short gonadotropin-releasing hormone (GnRH) agonist, GnRH antagonist, or GnRH agonist microdose flare; supernumerary good-quality blastocysts cryopreserved on days 5 or 6 after retrieval. Main Outcome Measures(s) Supernumerary good-quality blastocysts for cryopreservation in relation to AMH levels. Result(s) Among women <35 years of age, there was a statistically significant difference in the number of patients with supernumerary good-quality blastocysts for cryopreservation between the groups with AMH <1 ng/mL and AMH 1–4 ng/mL (30.0% vs. 58.4%) when adjusted for age. Among women ≥35 years of age, there was a statistically significant difference in the number of patients with supernumerary good-quality blastocyst cryopreservation between groups with AMH <1 ng/mL and AMH 1–4 ng/mL (16.1% vs. 42.6%), when adjusted for age. Conclusion(s) Low AMH levels are associated with a statistically significantly lower likelihood of blastocysts for cryopreservation as compared with higher AMH levels. This effect was seen among women both <35 and ≥35 years of age. Patient counseling should include realistic expectations for the probability of good-quality supernumerary blastocysts available for cryopreservation.