Details

Autor(en) / Beteiligte

• Vegh, Z.
• Burisch, J.
• Pedersen, N
• Kaimakliotis, I
• Duricova, D.
• Bortlik, M.
• Vinding, K. Kofod
• Avnstrøm, S
• Olsen, J.
• Nielsen, K. R.
• Katsanos, K. H.
• Tsianos, E. V.
• Lakatos, L.
• Schwartz, D.
• Odes, S.
• D’Incà, R.
• Beltrami, M.
• Kiudelis, G.
• Kupcinskap, L.
• Jucov, A.
• Turcan, S.
• Barros, L. F.
• Magro, F.
• Lazar, D.
• Goldis, A.
• de Castro, L
• Hernandez, V
• Niewiadomski, O.
• Bell, S.
• Langholz, E.
• Munkholm, P.
• Lakatos, P. L.

Titel

Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort

Ist Teil von

• Journal of Crohn's and colitis, 2015-09, Vol.9 (9), p.747-753

Ort / Verlag

UK: Oxford University Press

Erscheinungsjahr

2015

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background and Aims: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis. Methods: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn’s disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients’ data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu]. Results: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93]. Conclusions: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.