Details

Autor(en) / Beteiligte

• Cheng, Q.R.
• Zhang, F.Q.
• Zhou, H.
• Pan, Z.Q.
• Liao, G.Y.

Titel

DNA cleavage activities of two dinuclear copper coordination polymers

Ist Teil von

• Journal of coordination chemistry, 2015-06, Vol.68 (11), p.1997-2005

Ort / Verlag

Abingdon: Taylor & Francis

Erscheinungsjahr

2015

Quelle

Taylor & Francis

Beschreibungen/Notizen

• The DNA cleavage activities of two coordination polymers of Robson-type macrocycles, {[Cu 4 L 1 (4,4′-bipy) 2 ](ClO 4 ) 4 ·H 2 O} ∞ (1) and {[Cu 4 L 2 (4,4′-bipy) 4 ](ClO 4 ) 4 ·2CH 3 CN·2H 2 O} ∞ (2) (where H 2 L 1 and H 2 L 2 are the [2 + 2] condensation products of 1,3-diaminopropane with 2,6-diformyl-4-methylphenol and 2,6-diformyl-4-fluorophenol, respectively), have been studied. The interactions of the complexes with calf thymus-DNA were investigated by UV-vis spectroscopy, CD spectroscopy, and gel electrophoresis. The binding constants of 1 and 2 are 7.2 × 10 4 and 2.1 × 10 5  M −1 , respectively. The complexes exhibit DNA cleavage activity, with the cleavage process involving oxidative cleavage of DNA. The DNA cleavage activities of two new coordination polymers of Robson-type macrocycles, {[Cu 2 L 1 (bipy)]·(ClO 4 ) 2 ·CH 3 CN} ∞ (1) and {[Cu 2 L 2 (bipy)]·(ClO 4 ) 2 ·H 2 O} ∞ (2), have been studied. The interactions of the complexes with calf thymus-DNA were studied by UV-vis and CD spectroscopic techniques. The complexes exhibit good DNA cleavage activity. The results show that the substituent on the benzene ring plays an important role in DNA cleavage and the cleavage process occurs via oxidative cleavage.