Details

Autor(en) / Beteiligte

• Datema, Mareen R., MSc
• Zuidmeer-Jongejan, Laurian, PhD
• Asero, Riccardo, MD
• Barreales, Laura, MD
• Belohlavkova, Simona, MD
• de Blay, Frédéric, MD
• Bures, Peter, MD
• Clausen, Michael, MD
• Dubakiene, Ruta, MD
• Gislason, David, MD
• Jedrzejczak-Czechowicz, Monika, MD, PhD
• Kowalski, Marek L., MD, PhD
• Knulst, André C., MD, PhD
• Kralimarkova, Tanya, MD
• Le, Thuy-My, MD, PhD
• Lovegrove, Alison, MD
• Marsh, Justin, PhD
• Papadopoulos, Nikolaos G., MD
• Popov, Todor, MD
• del Prado, Náyade, BSc
• Purohit, Ashok, MD
• Reese, Gerald, PhD
• Reig, Isabel, MD
• Seneviratne, Suranjith L., MD, PhD
• Sinaniotis, Athanasios, MD
• Versteeg, Serge A., BSc
• Vieths, Stefan, PhD
• Zwinderman, Aeilko H., PhD
• Mills, Clare, PhD
• Lidholm, Jonas, PhD
• Hoffmann-Sommergruber, Karin, PhD
• Fernández-Rivas, Montserrat, MD, PhD
• Ballmer-Weber, Barbara, MD
• van Ree, Ronald, PhD

Titel

Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Ist Teil von

• Journal of allergy and clinical immunology, 2015-08, Vol.136 (2), p.382-391

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Hazelnut allergy is birch pollen–driven in Northern/Western Europe and lipid transfer protein–driven in Spain and Italy. Little is known about other regions and other allergens. Objective Establishing a molecular map of hazelnut allergy across Europe. Methods In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP. Results Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen–driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium , plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen. Conclusions In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.