Neuroscience, 2015-09, Vol.303, p.503-514
2015
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- Autor(en) / Beteiligte
- Titel
- Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper
- Ist Teil von
- Neuroscience, 2015-09, Vol.303, p.503-514
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • GABAergic blockade into the MT caused panic-like defensive behavior. • AEA injections in the SNpr decreased of defensive behavior of mice confronted with snake. • AEA into the SNpr caused a reduction of panic-like behavior of mice treated with GABAergic antagonist in the MT. • CB1 RS seems to be located mainly in presynaptic terminals of the striatonigral pathway. • eCBs mechanisms modulate the activity of nigrotectal GABAergic pathways decreasing the activity of striatonigral links.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2015.06.048Titel-ID: cdi_proquest_miscellaneous_1709179097
- Format
- –
- Schlagworte
- Animals, Arachidonic Acids - pharmacology, Bicuculline - pharmacology, Bothrops alternatus, Bothrops alternatus venomous snakes, Crotalid Venoms, dorsal periaqueductal gray matter (dPAG), endocannabinoids, Endocannabinoids - metabolism, Endocannabinoids - pharmacology, Escape Reaction - drug effects, Fear - drug effects, Fear - physiology, Fear - psychology, Functional Laterality, GABA-A Receptor Antagonists - pharmacology, gamma-Aminobutyric Acid - metabolism, Immobility Response, Tonic - drug effects, Immobility Response, Tonic - physiology, Male, Mice, Mice, Inbred C57BL, Neural Pathways - drug effects, Neural Pathways - physiology, Neurology, panic-related behavior, Pars Compacta - drug effects, Pars Compacta - physiology, Polyunsaturated Alkamides - pharmacology, Receptor, Cannabinoid, CB1 - metabolism, Signal Transduction - drug effects, Signal Transduction - physiology, substantia nigra pars reticulata (SNpr), Synaptophysin - metabolism, Tectum Mesencephali - metabolism, Viperidae