Details

Autor(en) / Beteiligte

• Hyde, Matthew J
• Clarke, Lynne
• Griffin, Julian L
• Herrera, Emilio
• Byrne, Christopher D
• Kemp, Paul R

Titel

single enteral feed prior to the commencement of parenteral nutrition ameliorates the incidence of steatosis in parenterally fed neonatal piglets

Ist Teil von

• Metabolomics, 2011-03, Vol.7 (1), p.118-125

Ort / Verlag

Boston: Boston : Springer US

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Total parenteral nutrition (TPN) in neonates is associated with liver dysfunction. The initial post-partum enteral feed plays a key role in establishing post-partum metabolic regulation. Therefore absence of enteral nutrition, in neonates commencing TPN immediately post-partum, may induce metabolic abnormalities driving liver dysfunction associated with TPN. To study the effect of a single enteral feed prior to commencing TPN on the aetiology of liver dysfunction in neonatal piglets maintained on TPN for 7 days. Piglets were delivered by caesarean section on day 112 of gestation. They were divided into two groups, receiving either no enteral intake (N) or a single 10 ml feed of sows milk (EF) before being fed by TPN for 7 days, after which tissue samples were taken. Hepatic lipid metabolism and enzyme activity were assessed coupled with metabolomic profiles. Piglets receiving no enteral nutrition accumulated more hepatic lipid (N 7.58 ± 0.84, EF 5.21 ± 0.30 g lipid·100 g of liver⁻¹, P = 0.013). Hepatic PEPCK activity was increased in EF piglets (N 8.59 ± 0.95, EF 10.57 ± 1.38 U·mg protein⁻¹, P = 0.024), alongside reduced hepatic lactate and key amino acid concentrations and increased muscle glucose. A single enteral feed immediately after birth alters hepatic metabolism, possibly by switching from lipid biosynthesis to gluconeogenesis, thereby reducing hepatic steatosis that occurs in response to TPN.