Details

Autor(en) / Beteiligte

• El-Feky, Said A.H.
• Abd El-Samii, Zakaria K.
• Osman, Nermine A.
• Lashine, Jasmine
• Kamel, Mohamed A.
• Thabet, Hamdy Kh

Titel

Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II

Ist Teil von

• Bioorganic chemistry, 2015-02, Vol.58, p.104-116

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] •New quinolines incorporated pyrazoles were synthesized.•Screening of anti-inflammatory, analgesic, and ulcerogenic activities were performed for the synthesized compounds.•Molecular modeling study was performed for compounds (5–11). In continuation of our study of novel quinolines with anti-inflammatory activity using the Pfitzinger reaction, several new quinoline derivatives were synthesized and tested for their anti-inflammatory and ulcerogenic effect. A docking study on the COX-2 binding pocket was carried out for the target compounds to rationalize the possible selectivity of them against COX-2 enzyme. The most active compounds (5a, 8a and 11a) were found to be superior to celecoxib. Compound 11a demonstrated the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site. Moreover, compounds 9c, 9e, 10a and 11a were devoid of ulcerogenic activity.