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Immunotherapy in acute myeloid leukemia
Cancer, 2015-08, Vol.121 (16), p.2689-2704
Grosso, Dolores A.
Hess, Rosemary C.
Weiss, Mark A.
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Grosso, Dolores A.
Hess, Rosemary C.
Weiss, Mark A.
Titel
Immunotherapy in acute myeloid leukemia
Ist Teil von
Cancer, 2015-08, Vol.121 (16), p.2689-2704
Ort / Verlag
United States
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Despite the remarkable progress made in some leukemias such as CML and CLL, cytotoxic treatment for AML remains essentially unchanged over the last 4 decades. Several lines of evidence, including the graft versus leukemia effect associated with allogeneic hematopoietic stem cell transplantation (HSCT), suggest that immunotherapy is an active modality in AML. Given the lack of progress for chemotherapy in this disease, many novel immunologic treatment approaches have been explored. The goals of non‐transplant‐based immune approaches have largely consisted of the stimulation or restoration of endogenous immune responses or the targeting of specific tumor antigens by immune cells. These strategies have been associated with less toxicity than allogeneic HSCT but typically have inferior efficacy. Allogeneic HSCT exploits major and minor histocompatibility differences between the donor and recipient in order to recognize and eradicate malignancy. With the recognition that the immune system itself provides a basis for treating AML, immunotherapy continues to be an attractive modality to exploit in the treatment of this disease. Cancer 2015;121:2689‐2704. © 2015 American Cancer Society The authors review immunologic strategies that have been used in the treatment of acute myeloid leukemia. Areas addressed include transplantation and nontransplantation immunologic approaches to acute myeloid leukemia treatment as well as newer therapies, such as chimeric antigen receptors and bispecific T‐cell engagers.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.29378
Titel-ID: cdi_proquest_miscellaneous_1709165908
Format
–
Schlagworte
acute myeloid leukemia
,
Antibodies, Bispecific - therapeutic use
,
Antibodies, Monoclonal - therapeutic use
,
Antigens, CD
,
Cancer Vaccines - therapeutic use
,
Cell Adhesion Molecules - antagonists & inhibitors
,
Cytokines - therapeutic use
,
Hematopoietic Stem Cell Transplantation
,
Humans
,
Immunotherapy
,
Killer Cells, Natural - immunology
,
Leukemia, Myeloid, Acute - therapy
,
monoclonal antibody therapy with or without toxins
,
Radioimmunotherapy
,
Sialic Acid Binding Ig-like Lectin 3 - antagonists & inhibitors
,
vaccines
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