Details

Autor(en) / Beteiligte

• Bergman, Arthur J.
• Burke, Joanne
• Larson, Patrick
• Johnson-Levonas, Amy O.
• Reyderman, Larisa
• Statkevich, Paul
• Kosoglou, Teddy
• Greenberg, Howard E.
• Kraft, Walter K.
• Frick, Glenn
• Murphy, Gail
• Gottesdiener, Keith
• Paolini, John F.

Titel

Effects of Ezetimibe on Cyclosporine Pharmacokinetics in Healthy Subjects

Ist Teil von

• Journal of clinical pharmacology, 2006-03, Vol.46 (3), p.321-327

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• This single‐center, open‐label, 2‐period crossover study investigated the effects of multiple‐dose ezetimibe (EZE) on a single dose of cyclosporine (CyA). Healthy subjects received 2 treatments in random order with a 14‐day washout: (1) CyA 100 mg alone and (2) EZE 20 mg for 7 days with CyA 100 mg coadministered on day 7; EZE 20 mg alone was administered on day 8. AUC(0‐last) and Cmax geometric mean ratios (90% confidence interval) for ([CyA + EZE]/CyA alone) were 1.15 (1.07, 1.25) and 1.10 (0.97, 1.26), respectively. Tmax (∼1.3 hours) was similar with and without EZE (P >.200). Mean CyA exposure slightly increased (∼15%) with multiple‐dose EZE 20 mg; however, this value was contained within (0.80, 1.25). The implications for chronic EZE dosing within the usual clinical paradigm of chronic CyA dosing have not been established; caution is recommended when using these agents concomitantly. CyA concentrations should be monitored in patients receiving EZE and CyA.