Details

Autor(en) / Beteiligte

• Kim, Kyung-Soo
• Song, Yi-Sun
• Jin, Jiyong
• Joe, Jun-Ho
• So, Byung-Im
• Park, Jun-Young
• Fang, Cheng-Hu
• Kim, Mi Jung
• Cho, Youl-Hee
• Hwang, Sejin
• Ro, Young-Suck
• Kim, Hyuck
• Ahn, You-Hern
• Sung, Hak-Joon
• Sung, Jung-Joon
• Park, Sung-Hye
• Lipton, Stuart A.

Titel

Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat

Ist Teil von

• Molecular and cellular endocrinology, 2015-10, Vol.414, p.64-72

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Effective treatment of diabetic neuropathy (DN) remains unsolved. We serendipitously observed dramatic relief of pain in several patients with painful DN receiving granulocyte-colony stimulating factor (G-CSF). The aim of this study was to determine if G-CSF could treat DN in an animal model and to ascertain its mechanism of action. In a rodent model of DN, G-CSF dramatically recovered nerve function, retarded histological nerve changes and increased the expression of neurotrophic factors within nerve. A sex-mismatched bone marrow transplantation (BMT) study revealed that G-CSF treatment increased the abundance of bone marrow (BM)-derived cells in nerves damaged by DN. However, we did not observe evidence of transdifferentiation or cell fusion of BM-derived cells. The beneficial effects of G-CSF were dependent on the integrity of BM. In conclusion, G-CSF produced a therapeutic effect in a rodent model of DN, which was attributed, at least in part, to the actions of BM-derived cells. •G-CSF recovered the function of DN-afflicted nerves.•G-CSF retard morphological changes associated with DN.•G-CSF treatment increased the abundance of BM-derived cells in nerves damaged by DN.•G-CSF increased expression of nerve trophic factors in nerves damaged by DN.•G-CSF receptors were expressed in Schwann cells.