Details

Autor(en) / Beteiligte

• Nielsen, Jonas B., MD
• Kühl, Jørgen T., MD
• Pietersen, Adrian, MD
• Graff, Claus, MSc, PhD
• Lind, Bent, MD, DMSci
• Struijk, Johannes J., MSc, PhD
• Olesen, Morten S., MSc, PhD
• Sinner, Moritz F., MD, MPH
• Bachmann, Troels N., BM
• Haunsø, Stig, MD, DMSci
• Nordestgaard, Børge G., MD, DMSci
• Ellinor, Patrick T., MD, PhD
• Svendsen, Jesper H., MD, DMSci
• Kofoed, Klaus F., MD, DMSci
• Køber, Lars, MD, DMSci
• Holst, Anders G., MD, PhD

Titel

P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study

Ist Teil von

• Heart rhythm, 2015-09, Vol.12 (9), p.1887-1895

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting. Objective The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF. Methods Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries. Results A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100–105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.41–1.81), intermediate (112–119 ms; HR 1.22, 95% CI 1.13–1.31), long (120–129 ms; HR 1.50, 95% CI 1.39–1.62), and very long P-wave duration (≥130 ms; HR 2.06, 95% CI 1.89–2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (≤89 ms; HR 1.20, 95% CI 1.06–1.34), long (120–129 ms; HR 1.11, 95% CI 1.04–1.19), and very long P-wave duration (≥130 ms; HR 1.30, 95% CI 1.21–1.40) compared with the reference group (106–111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke. Conclusion In a large primary care population we found both short and long P-wave duration to be robustly associated with an increased risk of AF.