Details

Autor(en) / Beteiligte

• Zhu, Lijing
• Liu, Fu
• Yu, Xuemin
• Xue, Lixin

Titel

Poly(Lactic Acid) Hemodialysis Membranes with Poly(Lactic Acid)-block-Poly(2-Hydroxyethyl Methacrylate) Copolymer As Additive: Preparation, Characterization, and Performance

Ist Teil von

• ACS applied materials & interfaces, 2015-08, Vol.7 (32), p.17748-17755

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Poly­(lactic acid) (PLA) hemodialysis membranes with enhanced antifouling capability and hemocompatibility were developed using poly­(lactic acid)-block-poly­(2-hydroxyethyl methacrylate) (PLA–PHEMA) copolymers as the blending additive. PLA–PHEMA block copolymers were synthesized via reversible addition–fragmentation (RAFT) polymerization from aminolyzed PLA. Gel permeation chromatography (GPC) and 1H-nuclear magnetic resonance (1H NMR) were applied to characterize the synthesized products. By blending PLA with the amphiphilic block copolymer, PLA/PLA–PHEMA membranes were prepared by nonsolvent induced phase separation (NIPS) method. Their chemistry and structure were characterized with X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM) and atomic force microscopy (AFM). The results revealed that PLA/PLA–PHEMA membranes with high PLA–PHEMA contents exhibited enhanced hydrophilicity, water permeability, antifouling and hemocompatibility. Especially, when the PLA–PHEMA concentration was 15 wt %, the water flux of the modified membrane was about 236 L m–2 h–1. Its urea and creatinine clearance was more than 0.70 mL/min, lysozyme clearance was about 0.50 mL/min, BSA clearance was as less as 0.31 mL/min. All the results suggest that PLA–PHEMA copolymers had served as effective agents for optimizing the property of PLA-based membrane for hemodialysis applications.