Details

Autor(en) / Beteiligte

• You, Lin
• Liang, Xin-Ting
• Xu, Ling-Min
• Wang, Yue-Fan
• Zhang, Jia-Jun
• Su, Qi
• Li, Yuan-He
• Zhang, Bo
• Yang, Shou-Liang
• Chen, Jia-Hua
• Yang, Zhen

Titel

Asymmetric Total Synthesis of Propindilactone G

Ist Teil von

• Journal of the American Chemical Society, 2015-08, Vol.137 (32), p.10120-10123

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• A concise total synthesis of (+)-propin­di­lactone G, a nor­tri­terpenoid isolated from the stems of Schisandra propinqua var. propinqua, has been achieved for the first time. The key steps of the synthesis include an asymmetric Diels–Alder reaction, a Pauson–Khand reaction, a Pd-catalyzed reductive hydrogen­olysis reaction, and an oxidative hetero­coupling reaction. These reactions enabled the synthesis of (+)-propin­di­lactone G in only 20 steps. As a consequence of our synthetic studies, the structure of (+)-propin­di­lactone G has been revised.