Details

Autor(en) / Beteiligte

• Bota, Simona
• Paternostro, Rafael
• Etschmaier, Alexandra
• Schwarzer, Remy
• Salzl, Petra
• Mandorfer, Mattias
• Kienbacher, Christian
• Ferlitsch, Monika
• Reiberger, Thomas
• Trauner, Michael
• Peck-Radosavljevic, Markus
• Ferlitsch, Arnulf

Titel

Performance of 2-D Shear Wave Elastography in Liver Fibrosis Assessment Compared with Serologic Tests and Transient Elastography in Clinical Routine

Ist Teil von

• Ultrasound in medicine & biology, 2015-09, Vol.41 (9), p.2340-2349

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Liver stiffness values assessed with 2-D shear wave elastography (SWE), transient elastography (TE) and simple serologic tests were compared with respect to non-invasive assessment in a cohort of 127 consecutive patients with chronic liver diseases. The rate of reliable liver stiffness measurements was significantly higher with 2-D SWE than with TE: 99.2% versus 74.8%, p < 0.0001 (different reliability criteria used, according to current recommendations). In univariate analysis, liver stiffness measured with 2-D SWE correlated best with fibrosis stage estimated with TE ( r  = 0.699, p < 0.0001), followed by Forns score ( r  = 0.534, p < 0.0001) and King's score ( r  = 0.512, p < 0.0001). However, in multivariate analysis, only 2-D SWE-measured values remained correlated with fibrosis stage ( p < 0.0001). The optimal 2-D SWE cutoff values for predicting significant fibrosis were 8.03 kPa for fibrosis stage ≥2 (area under the receiver operating characteristic curve = 0.832) and 13.1 kPa for fibrosis stage 4 (area under the receiver operating characteristic curve = 0.915), respectively. In conclusion, 2-D SWE can be used to obtain reliable liver stiffness measurements in almost all patients and performs very well in predicting the presence of liver cirrhosis.