Details

Autor(en) / Beteiligte

• Pressler, Susan J., PhD, RN
• Titler, Marita, PhD, RN
• Koelling, Todd M., MD
• Riley, Penny L., PhD, RN
• Jung, Miyeon, MSN, RN
• Hoyland-Domenico, Lisa, PhD, RN
• Ronis, David L., PhD
• Smith, Dean G., PhD
• Bleske, Barry E., PharmD
• Dorsey, Susan G., PhD, RN
• Giordani, Bruno, PhD

Titel

Nurse-Enhanced Computerized Cognitive Training Increases Serum Brain-Derived Neurotropic Factor Levels and Improves Working Memory in Heart Failure

Ist Teil von

• Journal of cardiac failure, 2015-08, Vol.21 (8), p.630-641

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Abstract Background Memory loss is common in heart failure (HF) patients, but few interventions have been tested to treat it. The objective of this study was to evaluate efficacy of a cognitive training intervention, Brain Fitness, to improve memory, serum brain-derived neurotropic factor (BDNF) levels, working memory, processing speed, executive function, instrumental activities of daily living, mobility, depressive symptoms, and health-related quality of life. Methods and Results Twenty-seven HF patients were randomly assigned to Brain Fitness and health education active control interventions. Data were collected at baseline and 8 and 12 weeks. Linear mixed models analyses were completed. Patients in the Brain Fitness group were older with lower ejection fraction. At 12 weeks, a group by time interaction effect was found for serum BDNF levels ( P  = .011): serum BDNF levels increased among patients who completed Brain Fitness and decreased among patients who completed health education. No differences were found in memory, but a group by time interaction ( P  = .046) effect was found for working memory. Conclusions Findings support efficacy of Brain Fitness in improving working memory and serum BDNF levels as a biomarker of intervention response. A randomized controlled study is needed among a larger more diverse group of HF patients.