Details

Autor(en) / Beteiligte

• Chen, Ming
• Ren, Zhi-Hui
• Wang, Yao-Yu
• Guan, Zheng-Hui

Titel

Palladium-Catalyzed Oxidative Carbonylation of the Alkenyl CH Bonds of Enamides: Synthesis of 1,3-Oxazin-6-ones

Ist Teil von

• Angewandte Chemie International Edition, 2013-12, Vol.52 (52), p.14196-14199

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2013

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Palladium and CO.: The title reaction proceeds in the presence of CO, thus providing a synthesis for 1,3‐oxazin‐6‐ones (see scheme; DABCO=1,4‐diazabicyclo[2.2.2]octane, DMF=N,N‐dimethylformamide). The reaction tolerates a variety of functional groups on both the aryl ring and the amide of the substrate. Initial mechanistic studies suggest the activation of the alkenyl CH bond to be a key step.