Angewandte Chemie (International ed.), 2012-06, Vol.51 (26), p.6516-6520
International ed. in English, 2012
Details
- Autor(en) / Beteiligte
- Titel
- Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing
- Ist Teil von
- Angewandte Chemie (International ed.), 2012-06, Vol.51 (26), p.6516-6520
- Auflage
- International ed. in English
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Eraserhead: Stem cells seem to erase epigenetic information by decarboxylation of the newly discovered epigenetic base 5‐carboxycytosine (caC; see picture). This reaction is likely to involve a nucleophilic attack of the C5C6 double bond.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.201202583Titel-ID: cdi_proquest_miscellaneous_1701120059
- Format
- –
- Schlagworte
- 5-carboxycytosine, Animals, Base Sequence, Bonding, Cytosine - analogs & derivatives, Cytosine - chemistry, Cytosine - metabolism, Decarboxylation, DNA - chemistry, Embryonic Stem Cells - chemistry, Embryonic Stem Cells - metabolism, epigenetics, Isotopes, isotopic labeling, Mice, Nitrogen Isotopes - chemistry, Oxidation-Reduction, Pictures, Stem cells