Angewandte Chemie (International ed.), 2012-05, Vol.51 (22), p.5381-5385
International ed. in English, 2012
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Details
- Autor(en) / Beteiligte
- Titel
- Rationally Designed Amide Donors for Organocatalytic Asymmetric Michael Reactions
- Ist Teil von
- Angewandte Chemie (International ed.), 2012-05, Vol.51 (22), p.5381-5385
- Auflage
- International ed. in English
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Amide nucleophiles on demand: Rationally designed pyrazoleamides function as Michael donors in urea‐catalyzed asymmetric Michael reactions with excellent chemical and optical yields (see scheme). The pyrazoleamide group performs as an ester equivalent, a directing group, an activating group, and functions as a good leaving group in further transformations of the product.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.201200996Titel-ID: cdi_proquest_miscellaneous_1701062050
- Format
- –
- Schlagworte
- Amides, Amides - chemistry, asymmetric synthesis, Asymmetry, Catalysis, cinchona alkaloids, Demand, Drug Design, Equivalence, Esters, Michael addition, Michael reaction, Molecular Structure, Nucleophiles, organocatalysis, Pyrazoles - chemistry, Stereoisomerism, Transformations (mathematics), Urea - pharmacology