Details

Autor(en) / Beteiligte

• Quitterer, Felix
• Beck, Philipp
• Bacher, Adelbert
• Groll, Michael

Titel

Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD)

Ist Teil von

• Angewandte Chemie International Edition, 2013-07, Vol.52 (27), p.7033-7037

Auflage

International ed. in English

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase. This catalyzed reaction includes an induced‐fit mechanism achieved by major structural rearrangements of the N‐terminal helix upon substrate binding. Different steps of the reaction trajectory are visualized by complex structures of PylD with substrate and product.