Details

Autor(en) / Beteiligte

• Beydoun, Kassem
• Ghattas, Ghazi
• Thenert, Katharina
• Klankermayer, Jürgen
• Leitner, Walter

Titel

Ruthenium-Catalyzed Reductive Methylation of Imines Using Carbon Dioxide and Molecular Hydrogen

Ist Teil von

• Angewandte Chemie (International ed.), 2014-10, Vol.53 (41), p.11010-11014

Auflage

International ed. in English

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The use of the well‐defined [Ru(triphos)(tmm)] catalyst, CO2 as C1 source, and H2 as reducing agent enabled the reductive methylation of isolated imines, as well as the direct coupling of amines with aldehydes and the subsequent reductive methylation of the in situ formed imines. The method, which afforded the corresponding N‐methyl amines in very good to excellent yields, was also used for the preparation of the antifungal agent butenafine in one step with no apparent waste, thus increasing the atom efficiency of its synthesis. Tertiary N‐methylamines were obtained in good to excellent yields through the reductive methylation of imines (used as such or formed in situ from amines and aldehydes, see scheme). Apart from the well‐defined [Ru(triphos)(tmm)] catalyst, CO2 was used as the C1 source, and H2 as the reducing agent. This method enabled the preparation of the antifungal agent butenafine in one step with no apparent waste, thus increasing the atom efficiency of its synthesis.