Details

Autor(en) / Beteiligte

• Barreiro, Juliana Cristina
• de Campos Lourenço, Tiago
• Silva, Lorena Mara A
• Venâncio, Tiago
• Cass, Quezia Bezerra

Titel

High resolution magic angle spinning NMR as a tool for unveiling the molecular enantiorecognition of omeprazole by amylose-based chiral phase

Ist Teil von

• Analyst (London), 2014-03, Vol.139 (6), p.135-1354

Ort / Verlag

England

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Polysaccharide-based chiral stationary phases (CSP) demonstrate great versatility and higher chiral selectivity for a variety of chiral compounds in multimodal elution modes (normal, reverse and polar organic). The main role of CSP phenyl carbamate based derivatives as chiral selectors is the formation of diastereoisomeric complexes by means of π-π interaction, dipole-dipole, hydrogen bonding and/or inclusion complex mechanisms. Nevertheless, the mechanism behind their enantioselectivity requires clarification. High resolution magic angle spinning nuclear magnetic resonance spectroscopy ( 1 H HR/MAS NMR) has provided key information on the recognition process at the binding sites of the CSP surface. Herein we report the results obtained using omeprazole as a probe for these investigations. This work reports key information about the enantiorecognition of omeprazole at the binding sites of the polysaccharide-based chiral stationary phase.